Mainstream support for Office 2010 ended on Octoextended support ended on October 13, 2020. As of December 31, 2011, approximately 200 million licenses of Office 2010 were sold, before its discontinuation on January 31, 2013. Despite this, Office 2010 was a success for Microsoft, surpassing the company's previous records for adoption, deployment, and revenue for Office. Sales, however, initially were lower than those of its predecessor. Reviews of Office 2010 were generally very positive, with praise to the new Backstage view, new customization options for the ribbon, and the incorporation of the ribbon into all programs. It is the last version of Microsoft Office to support Windows XP SP3, Windows Server 2003 SP2, Windows Vista and Windows Server 2008 as the following version, Microsoft Office 2013 only supports Windows 7, Windows Server 2008 R2, or later.

Office 2010 is compatible with Windows XP SP3 32-bit, Windows Server 2003 SP2 32-bit through Windows 10 and Windows Server 2016.

It is also the first version to require volume license product activation. Office 2010 is the first version of Office to ship in an 圆4 version. Office Mobile 2010, an update to Microsoft's mobile productivity suite was released on as a free upgrade from the Windows Phone Store for Windows Mobile 6.5 devices with a previous version of Office Mobile installed. A new Office Starter 2010 edition replaces Microsoft Works. It debuted Office Online, free Web-based versions of Excel, OneNote, PowerPoint, and Word. Collaborative editing features that enable multiple users to share and edit documents extended file format support integration with OneDrive and SharePoint and security improvements such as Protected View, a sandbox to protect users from malicious content are among its other new features. The ribbon introduced in Office 2007 for Access, Excel, Outlook, PowerPoint, and Word is the primary user interface for all applications in Office 2010 and is now customizable. Office 2010 introduces user interface enhancements including a Backstage view that consolidates document management tasks into a single location.

The macOS equivalent, Microsoft Office 2011 for Mac was released on October 26, 2010. Microsoft Office 2010 (codenamed Office 14 ) is a version of Microsoft Office for Microsoft Windows that was released to manufacturing on Ap and was later made available to retail on J as the successor to Office 2007 and the predecessor to Office 2013. English, Arabic, Bulgarian, Chinese (Simplified), Chinese, Croatian, Czech, Danish, Dutch, Estonian, Filipino, Finnish, French, German, Greek, Hebrew, Hindi, Hungarian, Italian, Japanese, Kazakh, Korean, Latvian, Lithuanian, Norwegian (Bokmål), Polish, Portuguese (Brazil), Portuguese (Portugal), Romanian, Russian, Serbian, Slovak, Slovenian, Spanish, Swedish, Thai, Turkish, Ukrainian

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